Asymmetric Synthesis of (−)-1-Hydroxyquinolizidinone, a Common Intermediate for the Syntheses of (−)-Homopumiliotoxin 223G and (−)-Epiquinamide

The short and efficient asymmetric synthesis of (−)-1-hydroxyquinolizidinone was achieved in seven steps and 25.2% overall yield from readily available 5-chloropentanal. It is a key intermediate in the formal syntheses of (−)-homopumilotoxin 223G and (−)-epiquinamide.