Fertility Activity of Wedelia trilobata Linn. Leaf Extracts on Female Wister Albino Rats

Wedelia trilobata Linn., Asteraceae, is a creeping evergreen perennial herb. It is native to the tropics of Central America and has naturalized in many wet tropical and subtropics areas of the world. It is widely used in traditional medicine for the treatment of contraceptives, rheumatoid arthritis, diabetes, infertility and impotence. The present study evaluated the potential fertility effect of aqueous and ethanolic extract of leaves of Wedelia trilobata Linn. Anti-oxidant activity of the leaves was determined and the antimicrobial activity was performed for the urinary bacteria of females. In animal experiment, Group 1 served as negative control given only olive oil, Group 2 and 3 were given with 200 mg/kg and 400 mg/ kg of Aqueous extract of W. trilobata , Group 4 and 5 – 3 was given with 200 mg/kg and 400 mg/kg of ethanolic extract of W. trilobata , Group 6 and 7 were given 1mg/kg and 2 mg/ kg of drug. The results revealed the promising anti-oxidant and anti-microbial activity and the aqueous treated rats shown similar activity compared to the control rat. The contraceptive nature of the rats was determined through the hormonal reports.