Reactive Oxygen Correlated Chemiluminescent Imaging of Semiconducting Polymer Nanoplatform for Monitoring Chemodynamic Therapy.

Chemodynamic therapy (CDT): Real-time monitoring reactive oxygen species (ROS) production is critical to reduce the nonspecific damage during CDT and to feasibly evaluate the therapeutic response. However, CDT agents that can emit ROS-related signals are rare. Herein, we synthesize a semiconducting polymer nanoplatform (SPN) that can not only produce highly toxic ROS to kill cancer cells but also emit ROS correlated chemiluminescent signals. Notably, the efficacy of both chemiluminescence and CDT can be significantly enhanced by Hemin doping (~10 folds enhancement for luminescent intensity). Such ROS-dependent chemiluminescence of SPN allows ROS generation within tumor to be optically monitored during CDT process. Importantly, SPN establish an excellent correlation of chemiluminescence intensities with cancer inhibition rates in vitro and in vivo. Thus, our nanoplatform represents the first intelligent strategy that enables chemiluminescence-imaging monitored CDT, which is potential to assess therapeutic ...