2-aminotetralin derivatives as antagonists of mu opioid receptor

Compound of formula (I): Formula ** ** in which R1 is -ORa or -C (O) NRbRc, R2, R3 and R4 are each independently C1-3 alkyl; R5 is selected from hydrogen, -CH2-cyclohexyl, benzyl, -CH2OH and C (O) OH; R6 is hydrogen or C1-3 alkyl; R7 is selected from hydrogen -C (O) R8, -C (O) NHR 9, -C (S) NHR10, -S (O) 2R11, and C1-6alkyl opcionalmentesustituido with -C (O) NH2, -OH, -CN, -O (CH2) 2OCH3, cyclohexyl or phenyl, wherein cyclohexyl and phenyl are each optionally substituted with one ofthem or two halo; R8 is selected from phenyl, benzyl, C5-6cicloalquilo, furanyl, thiophenyl, and C1-6alkyl, wherein phenyl, benzyl and C5-6cicloalquilo are optionally substituted with one or two halo or -S (O) 2NH2, and C1 -6alquilo is opcionalmentesustituido with one or two substituents selected from -OH, -C (O) ORa, -C (O) NH2, -S (O) 2CH3, phenyl and -OCH2OCH3; R9 is selected from C1-6 alkyl, phenyl, benzyl and -CH2-cyclohexyl, wherein phenyl and benzyl are each ofthem optionally substituted with one or two substituents selected from halo, -OCH3, and -CF3; R10 is selected from C1- it 6alquilo, phenyl and benzyl wherein each of phenyl and benzyl are opcionalmentesustituidos by one or two halo; R11 is selected from C1-6alkyl it, cyclohexyl and phenyl, where phenyl is optionally substituted by -NHC (O) CH3 or 1 to 5 fluoro; Ra, Rb and Rc are each independently hydrogen or C 1-3 alkyl; n is 0 or 1; wherein the substituents on the chiral centers marked by asterisks are in the trans configuration, provided that when R1 is -ORa, then at least one of R5 and R7 is not hydrogen or C1-6alkyl; or a pharmaceutically acceptable salt acceptable salt thereof.