Indazole derivatives, benzoxazole and pyrazolopyridine as p38 kinase inhibitors

A compound, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, said compound having the formula XVII: Formula ** ** where Y is O, NR2; W is CR3; R3 is H, NH2, F, Cl, methyl or substituted methyl; R2 is H, OH, an amine protecting group, Zn-NRaRb, Zn-NRa (C> = O) Rb, Zn-SO 2 R, SOR-Zn, Zn-SRa, Zn-ORa, Zn- (C> = O ) Ra, Zn- (C> = O) ORa, Zn-O- (C> = O) Ra, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl, wherein said cycloalkyl is saturated or partially unsaturated, Zn-heterocycloalkyl wherein said heterocycloalkyl is saturated or partially unsaturated, or Zn-Ar1, wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl, Zn-heterocycloalkyl, and Zn- Ar1 may be substituted or unsubstituted; Ar1 is aryl or heteroaryl, each of which may be substituted or unsubstituted; Ra and Rb are independently H, OH, an amino protecting group, a protecting group of alcohol, an acid protecting group, a protecting group for sulfur, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy , heteroalkoxy, Zn-cycloalkyl, wherein said cycloalkyl is saturated or partially unsaturated, Zn-heterocycloalkyl wherein said heterocycloalkyl is saturated or partially unsaturated, or Zn-Ar1, wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl , heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl, Zn-heterocycloalkyl, and Zn- Ar1 may be substituted or unsubstituted, or Ra and Rb together with the atoms to which they are both attached form a saturated heterocycle or partially unsaturated ring It has one or more heteroatoms in said ring, wherein said heterocycle may be substituted or unsubstituted and wherein said heterocycle may be fused with or n aromatic ring; Z is alkylene having 1 to 4 carbons, or alkenylene or alkynylene each having from 2 to 4 carbons, wherein said alkylene, alkenylene, or alkynylene may be substituted or unsubstituted; n is 0 or 1; U is CRc or N; V is CRc or N; Rc is H. F, Cl, methyl or substituted methyl; X is O, S, SO, SO2, NR5, C> = O, CH2, CH2Zn-OH, or C> = nord; R5 is H, methyl or substituted methyl; Rd is H, PO3H2, SO3H2, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl, wherein said cycloalkyl is saturated or partially unsaturated, Zn-heterocycloalkyl, wherein said heterocycloalkyl is saturated or partially unsaturated, or Zn-Ar1, wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl, Zn-heterocycloalkyl, and Zn- Ar1 may be substituted or unsubstituted, G, K, J and T are independently N or CRZ, provided that when any of said G, K, J and T are N the total number of G, K, J, or T that is N does not exceed 2; Rz is H, F, Cl, Br, CF3, OR6, SR6, lower alkyl (C1-C4), CN, or NR6R7; R6 and R7 are independently H, CF3, lower alkyl (C1-C4) or lower heteroalkyl (C1-C4); Q is -NR8CONH-, -NHCO-, -NR8SO2NH-, -NHSO 2, -CONR11-; R8 is H or lower alkyl (C1-C4); R11 is H or lower alkyl (C1-C4); Rx is - (CR9R10) m-, -O (CR9R10) m-, -NH (CR9R10) m-, or -S (CR9R10) m- provided that Q is -CONR11- when Rx is -O ( CR9R10) m-, -NH (CR9R10) m-, or -S (CR9R10) m-; R9 and R10 are independently H, or lower alkyl, or R9 and R10 together with the atoms to which they are both attached form a cycloalkyl ring which may be saturated or partially unsaturated; m is 1-3; Ry is H, PO 3 H, a protecting group of amino, oxygen protecting group, alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl wherein said cycloalkyl is saturated or partially unsaturated, Zn-heterocycloalkyl wherein said heterocycloalkyl is saturated or partially unsaturated, or Zn-Ar2, wherein said alkyl, allyl, alkenyl, alkynyl, heteroalkyl, heteroallyl, heteroalkenyl, heteroalkynyl, alkoxy, heteroalkoxy, Zn-cycloalkyl, Zn- Ar2, and Zn-heterocycloalkyl may be substituted or unsubstituted.