Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
2010
Abstract Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency ( K i ) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles.
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