Chromosomal Reorganization for the Expression of Recessive Mutation of Retinoblastoma Susceptibility Gene in the Developmentof Osteosarcoma1

The present invention relates generally to a novel CREBa polypeptide isoform, polynucleotides encoding the polypeptide, expression constructs comprising the polynucleotides, host cell transformed or transfected with the polynucleotides, methods for producing the polypeptide, and methods to identify inhibitors of binding between the CREBa and other polypeptides or polynucleotides.