Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates

Leanna Staben,Jinhua Chen,Josefa dela Cruz-Chuh,Geoffrey Del Rosario,Mary Ann Go,Jun Guo,Siamak Cyrus Khojasteh,Katherine R. Kozak,Guangmin Li,Carl Ng,Gail Lewis Phillips,Thomas H. Pillow,Rebecca K. Rowntree,John S. Wai,Binqing Wei,Keyang Xu,Zijin Xu,Shang-Fan Yu,Donglu Zhang,Peter S. Dragovich

Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates

2020

Cytotoxic pyrrolobenzodiazepine (PBD)-dimer molecules are frequently utilized as payloads for antibody–drug conjugates (ADCs), and many examples are currently in clinical development. In order to f...

Keywords:

Payload
systematic variation
Chemistry
Conjugate
Drug
Tolerability
Pyrrolobenzodiazepine
Antibody
Combinatorial chemistry
Dimer

Correction
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