Genetics of atherosclerosis

INTRODUCTION 171 HIERARCHICAL ORGANIZATION OF CAUSES OF CORONARY ARTERY DISEASE (CAD) ... . ... . . ... . . 172 INTERMEDIATE QUANTITATIVE RISK FACTOR TRAITS FOR GENETIC STUDIES OF CAD 173 GENETIC ARCHITECTURE OF QUANTITATIVE RISK FACTOR TRAITS 174 STRATEGIES USED IN THE STUDY OF GENETIC ARCHITECTURE OF QUANTITATIVE RISK FACTOR TRAITS 176 Top-Down, an Unmeasured Genotype Approach. .... . . . . . . . . ..... . . . . . . . . . . . . . . . . . . . .. . . . . 176 Bottom-Up, a Measured Genotype Approach . . ......... . 179 A Hybridization of Strategies . . ......... 182 CHALLENGES FOR FUTURE RESEARCH .... ...... 182