Compounds, compositions and methods of treating heart failure

A compound represented by Formula (I): ** ** Formula wherein: R1 is represented by Formula II: Formula ** ** X is O; Y and Z are C; R11 is 1-acyl-pyrrolidin-3-yl, 1-alkoxycarbonyl-pyrrolidin-3-yl, 1-amidino-pyrrolidin-3-yl, 1-sulfonyl-pyrrolidin-3-yl, 3-oxo-tetrahydro-pyrrolo [ 1,2-c] oxazol-6-yl, 1-alkoxycarbonyl-piperidin-yl 3-yl-3, 1-amidino-piperidin-yl, 1-acyl-piperidin-3-piperidin 1-sulfonyl-3- yl, optionally having a substituent on the C1-C4 alkoxy or alkoxyalkyl C1-C4, 1-acetyl-piperidin yl-3-yl 1-methoxyacetyl-piperidin-3-, 1- (azetidine-1-carbonyl) - piperidin-3-yl, 1-methoxycarbonyl-piperidin-3-yl, 1-, 1-dimethylaminocarbonyl-piperidin-3-yl, 1-methanesulfonyl-piperidin-3-yl, 1- ethoxycarbonyl-piperidin-yl-3 (ethane -2-sulfonyl) -piperidin-3-yl, 1- (propane-2-sulfonyl) -piperidin-3-yl, 1- (azetidin-1-yl-sulfonyl) -piperidin-3-yl, 1- dimethylamino- sulfonyl-piperidin-3-yl, 1- (N1-azetidin-1-yl-N2-cyano-amidino) -piperidin-3-yl, 1- (N2-cyano-N1, N1- dimetiamidino) -piperidin-3- yl, 1-acetyl-pyrrolidin-3-yl, 1-methoxyacetyl-pyrrolidin-3-yl, 1- (azetidine-1-carbonyl) - pyrrolidin-3-yl, 1-metoxicar Bonil-pyrrolidin-3-yl, 1-methoxycarbonyl-2-methoxymethyl-pyrrolidin-4-yl, 1-methanesulfonyl-pyrrolidin-3-yl, 1- (ethane-2-sulfonyl) -pyrrolidin-3-yl, 1- (ethane-2-sulfonyl) -4-methoxy-pyrrolidin-3-yl, 1- (ethane-2-sulfonyl) -5-methoxymethyl-pyrrolidin-3-yl, 1- (propane-2-sulfonyl) -pirrolidin- 3-yl, 1- (azetidin-1-yl-sulfonyl) -pyrrolidin-3- yl, 1-dimethylaminosulfonyl-pyrrolidin-3-yl, 1-dimethylaminosulfonyl-2-methoxymethyl-pyrrolidin-4-yl, 1- (N1 -azetidin-1-yl- N2-cyano-amidino) -pyrrolidin-3-yl, 1- (N2-cyano-N1, N1-dimetiamidino) -pyrrolidin-3-yl or 1-oxo- tetrahydro-pyrrolo [c -3- ] oxazol-6-yl. R1,2 is hydrogen; R1.3 is fluoro; and R2 is isooxazol-3-yl, isoxazole-5-5-methyl-isoxazole-3-yl, pyrazol-3-yl, pyrazinyl, phenyl having one or two substituents selected from: C1-C5, C1 C4, halo, hydroxy and C1-C5 hydroxyalkyl; pyridin-2-yl, pyridin-3-yl or pyridin-4-yl group having optionally a substituent selected from: acetyl, C1-C5, C1-C4 alkoxy, alkoxyalkyl C1-C4 alkoxycarbonyl C1-C4 alkyl, carboxy and trifluoromethyl. or a single stereoisomer, mixtures of stereoisomers