STUDY OF ANTIGENOTOXIC POTENTIAL OF THE ROSEHIP (ROSA MAJALIS HERRM.) OF THE FAMILY ROSACEAE

Increasing the body's resistance to various environmental pollutants' adverse effects is one ofmedicine's essential tasks. In this regard, an active search for antimutagens to eliminate or weaken mutagens' effectin the body is currently underway. One of the promising sources of antimutagenic compounds is the medicinal plantRosa majalis Herrm (rosehips). The genotoxic and antigenotoxic activity of rosehips was studied on cells of bonemarrow, spleen, liver, and kidneys of laboratory mice using an alkaline variant Comet assay. It was found thatrosehip infusions in various concentrations (infusion, diluted infusion and herbal tea) do not have a genotoxic effecton the cells of the studied organs of laboratory animals. The medicinal rosehip's combined action with classicalmutagen MMS significantly reduced (p<0.01) MMS-induced mutagenesis level. The various rosehip infusions useddid not show statistically significant differences among themselves. The results obtained indicate the antigenotoxicactivity of R. majalis infusions.