Electrochemical Oxidative Cyclization of N-Allylcarboxamides: Efficient Synthesis of Halogenated Oxazolines

Herein, we reported an efficient and sustainable intramolecular electrochemical cyclization of N-allylcarboxamides for the synthesis of various halogenated oxazolines. This method was conducted in a simple undivided cell by employing lithium halogen salts as redox mediums and halogen sources. A wide range of oxazolines, including five- and six-membered heterocycles, iodine-, bromo-, and chloro-methyl oxazolines were constructed in moderate to good yields at room temperature. Notably, this electrochemical oxidative cyclization obviates the use of external oxidants.