One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Chloroacetic Acid as Catalyst.
2007
A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.
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