ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines

Inna Georgieva,D. Koychev,Yawen Wang,Judith D. Holstein,Werner Hopfenmüller,Martin Zeitz,Patricia Grabowski

ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines

2010

Inna Georgieva
D. Koychev
Yawen Wang
Judith D. Holstein
Werner Hopfenmüller
Martin Zeitz
Patricia Grabowski

Background: Therapeutic approaches to gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are still not satisfactory. A new direction in treatment options could be the novel aur

Keywords:

ZM447439
Cell growth
Cell cycle
Aurora inhibitor
Endocrinology
Neuroendocrine tumors
Programmed cell death
Apoptosis
Cell cycle checkpoint
Internal medicine
Biology
Cell culture

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