Determination of the Adipic Acid Solubility Curve in Acetone by Using ATR-FTIR and Heat Flow Calorimetry

This contribution reports the determination of the solubility curve of adipic acid in acetone by using real-time ATR-FTIR and heat flow calorimetry. Focused beam reflectance measurement was used to detect the presence of insoluble adipic acid crystals. Theoretical evaluation based on the Nývlt equation was successfully used to achieve the temperature dependence of the solubility of adipic acid. The results obtained by evaluating the experimental and simulated data indicate that both procedures presented in this report can be used as process analytical tools to determine solubility curves.