Preparation method of full benzyl-protected beta-alkylglucoside

The invention discloses a preparation method of full benzyl-protected beta-alkylglucoside. The method is characterized by comprising the following steps of: mixing propineglucoside of full benzyl and a solvent in the ratio of 1mol:(10-100)L while stirring; adding an alcohol receptor while stirring; undergoing a glycosylation reaction in an FeCl3/C solid acid catalyst at the temperature of 20-100 DEG C; after the reaction, filtering the catalyst out; and concentrating and purifying a filtrate to obtain a product, i.e., full benzyl-protected beta-alkylglucoside, wherein the receptor is an alcohol selected from phenylcarbinol, methanol, propenol, n-butyl alcohol and the like; and the equivalent proportion of the receptor to propyne alcoholic glycoside is (1.0-5.0):1. Compared with the prior art, the preparation method has the advantages of simple process, convenience for operating, low cost, high yield, avoidance of the use of high-toxicity chemical raw materials and environmental friendliness, and is a synthetic method of full benzyl-protected beta-alkylglucoside which has a wider substrate application range and is environmentally-friendly, economical and efficient.