Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.

Jack J. Chen,Kumar D. Thakur,Michael Philip Clark,Steven K. Laughlin,Kelly M. George,Roger Gunnard Bookland,Jan Richard Davis,Edward J. Cabrera,Vijay Easwaran,Biswanath De,Y. George Zhang

Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.

2006

Jack J. Chen
Kumar D. Thakur
Michael Philip Clark
Steven K. Laughlin
Kelly M. George
Roger Gunnard Bookland
Jan Richard Davis
Edward J. Cabrera
Vijay Easwaran
Biswanath De
Y. George Zhang

A new class of pyrimidine-based Janus tyrosine kinase 3 (JAK3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK3.

Keywords:

Janus kinase
Enzyme
Pyrimidine
Tyrosine-kinase inhibitor
Tyrosine kinase
Biochemistry
Signal transduction
Organic chemistry
In vitro
Chemistry
Enzyme inhibitor
Janus

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations