Progress in Molecular Biology of Transmissible gastroenteritis virus of swine

Transmissible gastroenteritis virus of swine(TGEV) with a genome consisting of a large single stranded positive-sense RNA,code 4 structure protein and 3 non-structure protein.TGEV S protein is a point of the research and it was expressed efficiently in E.coli,Salmonella,adenovirus and so on in recent years.The genome of the TGEV has been engineered as an expression vector of an infectious cDNA,The vector led to the efficient and stable expression of a heterologous gene,inserted in the site previously occupied by the nonessential ORFs 3a and 3b.Gene 1 is conserved among the coronavirus,and it has important meaning in developing the medicine of TGEV and other Coronavirus.