Biocompatible Bovine Serum Albumin Stabilized Platinum Nanoparticles for Oxidation of Morin

Development of monodisperse and biocompatible platinum nanoparticles for organic dyes treatment has been drawing great interest. Herein, bovine serum albumin (BSA) was used to stabilize different amount of platinum nanoparticles (Ptn@BSA NPs, n =10, 15, 20), where Pt metal precursor (K2PtCl4) was incubated with BSA solution, followed by the addition of excess NaBH4 as reducing agent. The prepared Ptn@BSA NPs had small size with narrow distribution and good catalytic activity towards morin. The transmission electron microscopy (TEM) image demonstrated that the average sizes of Pt10@BSA, Pt15@BSA and Pt20@BSA were 1.70±0.39, 2.15±0.42 and 3.11±0.72 nm, respectively. The dynamic light scattering (DLS) results showed that the hydrodynamic sizes of Pt10@BSA, Pt15@BSA and Pt20@BSA were 4.25, 6.57 and 8.84 nm, the corresponding zeta potentials were -31.23, -30.2 and -29.77 mV, respectively. In addition, the oxidation of morin using Ptn@BSA NPs followed pseudo-first-order reaction in the presence of H2O2. The apparent rate constant Kapp was dependent on the concentration of Ptn@BSA NPs, morin and H2O2. Ptn@BSA NPs expedited the formation of hydroxyl radicals (•OH) from H2O2. More importantly, Ptn@BSA NPs were biocompatible towards HeLa cells. Taken together, Ptn@BSA could be employed as eco-friendly catalysts to treat organic dyes in the future.