Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor

Bin Wu,Sisi Zhang,Tao Hong,Yizong Zhou,Hui Wang,Min Shi,Hongwei Yang,Xiangguang Tian,Jing Guo,Jianwei Bian,James Roache,Pete Delgado,Ruowei Mo,Cary Fridrich,Feng Gao,Jianhua Wang

Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor

2020

Bin Wu
Sisi Zhang
Tao Hong
Yizong Zhou
Hui Wang
Min Shi
Hongwei Yang
Xiangguang Tian
Jing Guo
Jianwei Bian
James Roache
Pete Delgado
Ruowei Mo
Cary Fridrich
Feng Gao
Jianhua Wang

The scalable synthesis of an FXI (Factor XI) inhibitor employing multiple emerging technologies is described. The reduction of ketone to chiral alcohol was established through a biocatalysis approa...

Keywords:

Ketone
Combinatorial chemistry
Pulmonary surfactant
Chemistry
Biocatalysis
Chirality (chemistry)
Merge (version control)
continuous manufacturing
Factor XI inhibitor

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