Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity

In vivo and in vitro investigations of GilP and GilQ, two acyltransferases encoded by the gilvocarcin gene cluster, show that GilQ confers unique starter unit specificity when catalyzing an early as well as rate limiting step of gilvocarcin biosynthesis.