3-Arylisoindolinone and sesquiterpene derivatives from the mangrove endophytic fungi Aspergillus versicolor SYSU-SKS025

Abstract A pair of 3-arylisoindolinone enantiomers: (+)-asperglactam A ( 1 ), (−)-asperglactam A ( 1 ) and a pair of nor-bisabolane enantiomers: (+)-1-hydroxyboivinianic acid ( 2 ), (−)-1-hydroxyboivinianic acid ( 2 ), along with seven known compounds ( 3  −  8 ) were obtained from the mangrove endophytic fungus Aspergillus versicolor SYSU-SKS025. Their structures were determined on the basis of HRESIMS and NMR spectroscopic data, and X-ray diffraction. (+)-Asperglactam A ( 1 ) and (−)-asperglactam A ( 1 ) are the first optically pure examples in the 3-arylisoindolinone family, which are rarely found in natural sources. All isolated compounds were evaluated for α-glucosidase inhibitory activity. The enantiomers of 1  −  3 showed moderate inhibitory activity against α-glucosidase with IC 50 values ranging from 50 to 190 μM. Compound 7 exhibited significant inhibitory activity against α-glucosidase with IC 50 value of 7.5 μM. In addition, compound 7 was found to inhibit nitric oxide production in RAW 264.7 macrophages with IC 50 value of 12.5 μM.