Enhanced 3D-printed holographic acoustic lens for aberration correction of single-element transcranial focused ultrasound

The correction of the aberration of transcranial focused ultrasounds is a relevant issue for enhancing various non-invasive medical treatments. Emission through multi-element phased arrays has been the most widely accepted method to reduce aberrations in recent years; however, a new disruptive technology, based on 3D printed acoustic lenses, has recently been proposed with lower cost and comparable accuracy. The number and size of transducers in phased array configurations was a bottleneck limiting the focusing accuracy, but once the submillimeter precision of the latest generation 3D printers has overcome this limitation, the challenge is now to improve the accuracy of the numerical simulations needed to design the lens. This study introduces and evaluates two improvements to the numerical model applied in previous works that proposed 3D lenses, which consist in the direct calculation of the phase pattern from the propagation of oscillating magnitudes in complex form, and in the introduction of the absorption phenomenon into the set of equations that describe the dynamics of the wave in both fluid and solid media. Numerical experiments are performed analysing the quality of the aberrated-corrected focus in different configurations. The results obtained show that the inclusion of absorption significantly improves focusing, especially where the thickness of the skull is more irregular.