Synthesis, characterization, cytotoxicity and antimicrobial studies on Bi(III) dithiocarbamate complexes containing furfuryl group and their use for the preparation of Bi2O3 nanoparticles

Abstract Bismuth(III) dithiocarbamate complexes, tris(N-furfuryl-N-propyldithiocarbamato-S,S′)bismuth(III) ( 1 ), tris(N-furfuryl-N-butyldithiocarbamato-S,S′)bismuth(III) ( 2 ) and tris(N-furfuryl-N-benzyldithiocarbamato-S,S′)bismuth(III) ( 3 ), have been prepared and characterized by microanalysis, and spectroscopy (IR and NMR). Structure of 3 has been obtained by single crystal X-ray diffraction. This complex contains distorted pentagonal pyramidal Bi(III) centres which attain an overall distorted pentagonal bipyramidal coordination via long range intermolecular Bi⋯S interactions. DFT quantum mechanical studies of 3 were carried out, supporting the partial double bond character of C–N (thioureide) and C–S bonds in dithiocarbamate ligands. All the compounds have been screened against a panel of microbes viz . Vibrio cholerae , Bacillus subtilis , Klebsiella pneumoniae , Escherichia coli , Staphylococcus aureus , Aspergillus niger and Candida albicans. Complexes 1 and 3 were found to have better activity against K. pneumoniae , V. cholerae , A. niger and C. albicans than the complex 2 . Complexes 1 – 3 have been evaluated for their in vitro cytotoxic activity against KB cells. Complexes 1 and 3 showed higher activity than 2 . Bi 2 O 3 obtained from thermal decomposition of 3 has been characterized by PXRD, HRTEM, EDAX, UV–Vis and Fluorescence spectroscopy. PXRD study showed that the sample is composed of monoclinic phase of α-Bi 2 O 3 . Photocatalytic activity of as-prepared α-Bi 2 O 3 was determined by decolourization of rhodamine-B in aqueous solution under ultra violet irradiation.