AI Milano — History and Clinical Profile

Plasma apolipoproteins have been long considered as stable and invariable structures, characterized by the presence of long linear stretches and, particularly, by amphipathic helical segments. Although some apoprotein polymorphism was earlier suggested, based on the detection of apo E variations in type III hyperlipoproteinemia, the possibility that significant changes in the apolipoprotein structure might be associated with phenotypic abnormalities, seemed remote.