Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Yanping Xu,Daniel Ray Mayhugh,Ashraf Saeed,Xiaodong Wang,Richard Craig Thompson,Samuel J. Dominianni,Raymond F. Kauffman,Jaipal Singh,James S. Bean,William R. Bensch,Robert J. Barr,John Osborne,Chahrzad Montrose-Rafizadeh,Richard W. Zink,Nathan Yumibe,Naijia Huang,Debra Luffer-Atlas,Deepa Rungta,Dale E. Maise,Nathan Bryan Mantlo

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

2003

A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.

Keywords:

Organic chemistry
Agonist
Peroxisome proliferator-activated receptor
Biochemistry
Chemistry
triazole derivatives
In vitro
In vivo
Stereochemistry
pparα agonist
Chemical synthesis
α agonists

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations