Caloric availability of SALATRIM in rats and humans

SALATRIM is a reduced-calorie fat substitute composed of structured triacylglycerols. These structured triacylglycerolB are composed of long-chain fatty acids (predominantly stearic) and short-chain aliphatic acids (acetic, propionic, and/or butyric). It has been demonstrated in rat studies and in a clinical study that SALATRIM with various combinations of these aliphatic acid and fatty acid side chains delivers fewer calories per gram than conventional triacylglycerols such as corn oil. The reduced calories are accounted for by the lower caloric value of the short-chain aliphatic acids and limited absorption of the stearic acid which is freed by enzymatic hydrolyse in the gastrointestinal tract. In caloric availability studies with rats SALATRIM was found to deliver between 4.5 and 6.0 kcal/g