Design, Synthesis and Structure—Activity Relationships of 6‐O‐Arylpropargyl Diazalides with Potent Activity Against Multidrug‐Resistant Streptococcus Pneumoniae.

Hong Yong,Yu Gui Gu,Richard F. Clark,Thomas Marron,Zhenkun Ma,Niru B. Soni,Gregory G. Stone,Angela M. Nilius,Kennan Marsh,Stevan W. Djuric

Design, Synthesis and Structure—Activity Relationships of 6‐O‐Arylpropargyl Diazalides with Potent Activity Against Multidrug‐Resistant Streptococcus Pneumoniae.

2005

Hong Yong
Yu Gui Gu
Richard F. Clark
Thomas Marron
Zhenkun Ma
Niru B. Soni
Gregory G. Stone
Angela M. Nilius
Kennan Marsh
Stevan W. Djuric

A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens.

Keywords:

Microbiology
Antibiotics
Streptococcus pneumoniae
Organic chemistry
Multiple drug resistance
Chemistry
design synthesis

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