Diastereoselective hydrogenation of Formoterol intermediate over M(Ir, Pd, Pt, Rh, Ru)/BEA zeolite catalysts

Abstract The chemo- and diastereoselective hydrogenation of Formoterol intermediate (2-[N-benzoyl-N-[(R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-4’-benzoyloxy-3’ nitro acetophenone) ( 3 )) has been investigated on M(Ir, Pd, Pt, Rh, Ru)/BEA zeolite catalysts. Catalytic performances were well correlated with the catalysts characteristics. Both the chemo- and diastereoselectivity were influenced by the metal dispersion and its reduction degree. The obtained results also underlined the essential role of H-BEA as a selectivity-promoting support.