Standardization of Blood Collection and Processing for the Diagnostic Use of Extracellular Vesicles
2019
Purpose of Review
Extracellular vesicles (EVs) are lipid membrane vesicles released by many types of cells in both health and disease. EVs can be found in most body fluids, carrying a plethora of biomolecules, including proteins, RNA, and DNA, that reflect the biomolecular composition of the tissue of origin. Parenchymal and stromal cells actively release EVs in the extracellular milieu and in circulation, providing valuable information that may be exploited for diagnostic applications. However, isolation of these EV subpopulations in circulation is extremely challenging as they are diluted within more abundant EV subpopulations derived from blood cells (red blood cells, platelets, and white blood cells).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
50
References
12
Citations
NaN
KQI