АССОЦИАЦИЯ ПОЛИМОРФИЗМА ARG399GLN ГЕНА РЕПАРАЦИИ ДНК XRCC1 С РИСКОМ РАЗВИТИЯ НЕХОДЖКИНСКИХ ЛИМФОМ ВЫСОКОЙ СТЕПЕНИ ЗЛОКАЧЕСТВЕННОСТИ

Summary G. ene XRCC1 is a member of gene family involved in cell cycle and genome stability regulation. Oligonucleotide polymorphism Arg399Gln of this gene leads to substitution of arginine for glycine in the structure of the encoded protein and to a reduction of its activity. The polymorphic locus of XRCC1 gene codone was studied in 42 patients with aggressive non-Hodgkin’s lymphoma (NHL). A signifi cant increase in the incidence of XRCC1 gene rare homoxygotic genotype Gln/Gln was found in the patients with aggressive NHL variants vs. the population control (OR 2.3; CI 1.04—5.0; p < 0.05). The disease risk was the highest for diff use large B-cell lymphoma (OR 4.2; CI 1.42—12.9; p < 0.01). On the other hand, the risk of aggressive NHL was signifi cantly lower for individuals with Arg/Arg polymorphism vs. the population (OR 0.4; CI 0.17—0.95; p < 0.05).Key words: oligonucleotide polymorphism, XRCC1 gene, DNA repair, hemoblastosis, diff use large B-cell lymphoma, liability, riskometry