Concise Synthesis of 2,6-Disubstituted Morpholines by Cyclization of Epoxy Alcohols

A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines was developed by acid-catalyzed cyclization of epoxy alcohols. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)