Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

Raquel Ordonez and Nestor Prieto-Dominguez are supported by the program ‘Formacion del Profesorado Universitario’ (Becas FPU, references FPU12/01433 and FPU13/04173, respectively) from the Ministry of Education (Spain). CIBERehd is funded by Instituto de la Salud Carlos III, Spain. This work was supported in part by grants BFU2013-48141-R from Plan Nacional de I+D+I Spain, LE135U13 from Consejeria de Educacion de la Junta de Castilla y Leon, and SAF-2011-23031 and SAF-2012-34831 from Plan Nacional de I+D Spain; Fundacio Marato de TV3, La Mutua Madrilena, and PI11/0325 (META) grant from the Instituto Salud Carlos III; and by the center grant P50-AA-11999 from Research Center for Liver and Pancreatic Diseases funded by NIAAA/NIH