Biochemical Analysis oftheHuman Mismatch Repair Proteins hMutS MSH2 G674A -MSH6 and MSH2-MSH6 T1219D * □

mice that have mutations in or near the ATP binding site ofMSH2orATPhydrolysiscatalyticsiteofMSH6developcancerand have a reduced lifespan due to loss of the MMR pathway(Lin, D. P., Wang, Y., Scherer, S. J., Clark, A. B., Yang, K., Avdi-evich, E., Jin, B., Werling, U., Parris, T., Kurihara, N., Umar, A.,Kucherlapati, R., Lipkin, M., Kunkel, T. A., and Edelmann, W.(2004)