Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals

Abstract Objective Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naive HIV subjects (no AIDS). Methods EEG, clinical, and neuropsychological data were collected in 103 treatment-naive HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. Results Widespread sources of delta ( Conclusions Regional EEG abnormalities in quiet wakefulness characterized treatment-naive HIV subjects at the individual level. Significance This EEG approach may contribute to the management of treatment-naive HIV subjects at risk of cognitive deficits.