Rh(III)-Catalyzed Tandem Bicyclization of 2-Arylimidazo[1,2-a]pyridines with Cyclic Enones for the Construction of Bridged Scaffolds
2019
An efficient Rh(III)-catalyzed bicyclization of 2-arylimidazo[1,2-a]pyridine with cyclic enones has been developed for the synthesis of bridged imidazopyridine derivatives in excellent yields up to 95%. The reaction proceeds through a sequential conjugate addition of ortho-C–H bond of aryl group followed by an intramolecular C3-alkylation of imidazopyridine ring in a highly regioselective manner.
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