Hold in the palm his preparation method of pyrrole department

The invention belongs to field of medicine and chemical technology, and in particular to a kind of his preparation method of support pyrrole department.2 chlorine 4 [base of (base of 5 pyridine 4) 1H [1,2,4] triazole 3] pyridines in the presence of catalyst, alkali and part, using cyanylation agent, carry out cyanalation reaction, obtain holding in the palm pyrrole department he.Using 4 cyanopyridine N oxides as initiation material, 1,2 dichloroethanes is solvent, and triethylamine is alkali, does chlorinating agent using POCl3, carries out chlorination, obtain the cyanopyridine of 2 chlorine 4；For the cyanopyridine of 2 chlorine 4 with isoniazid in methanol solvate, sodium methoxide is catalyst, and condensation cyclization obtains 2 chlorine 4 [base of (base of 5 pyridine 4) 1H [1,2,4] triazole 3] pyridines.The present invention avoids the cyanylation agent using severe toxicity, reduces environmental hazard, product yield high-purity is good, is adapted to industrial mass production from the inexpensive cyano group source of safety.