Relationship between matrix metalloproteinase-9 gene-1562C/T polymorphism and hemorrhagic transformation from in Chinese Han population in Henan province

Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) gene -1562 C/T polymorphism and hemorrhagic transformation (HT) from (IS) in Chinese Han population in Henan province. Methods The promoter -1562 C/T gene polymorphism in 84 IS patients with HT and 138 age- and sex-matched IS patients without HT were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotypes and alleles frequencies of -1562 C/T polymorphism were analyzed. Results The frequency of CT and TT genotype and T allele was lower in IS patients with HT than in IS patients without HT (17.86% (15 cases) vs. 30.43% (42 cases), 8.93% (15 cases) vs. 15.94% (44 cases), χ2=4.326 and 4.458, P=0.037 and 0.035). The relative risk for HT from IS was decreased in patients with T allele than those with CT and TT genotype〔0.517 (95%CI: 0.278-0.961) vs. 0.497 (95%CI: 0.255-0.967)〕. Conclusions The MMP-9 gene-1562C/T polymorphism may be related to hemorrhagic transformation of in Chinese Han population in Henan province. The T allele is a protective factor for hemorrhagic transformation of in the population. Key words: Stroke; Matrix metalloproteinase 9; Polymorphism, single nucleotide