Cu(OAc)2 and Acids Promoted the Oxidative Cleavage of α-Aminocarbonyl Compounds with Amines: Efficient and Selective Synthesis of 2-t-Amino-2-imino-carbonyl and 2-Amino-2-oxocarbonyl

Abstract A novel and efficient method for the synthesis of 2-t-amino-2-imino-carbonyl (C) and 2-amino-2-oxocarbonyl (D) compounds has been discovered through a copper-promoted oxidating amidation reactions between α-amino -carbonyl compounds and amines. Promoted by the crucial copper species, perfect selectivity and good to excellent yields could be achieved. This transformation is achieved through C-N bond oxidative cleavage and formation a novel C-N bond. This reaction system has a broad reaction scope, providing a facile pathway for the α-functionalization of α-amino ketones.