Stereoselective synthesis of (+)-(8R,8aR)-perhydro-8-indolizidinol

Abstract A highly stereoselective total synthesis of (+)-(8 R ,8a R )-perhydro-8-indolizidinol is described. Key steps involved in this synthesis are diastereoselective zinc allylation, azido-olefin cyclization and reductive amination followed by cyclization which effectively constructed the indolizidine ring. This contributes a unique approach to the synthesis of indolizidine alkaloids that offers the advantages of brevity and relatively high overall yields.