T1ρ mapping improvement using stretched-type adiabatic locking pulses for assessment of human liver function at 3 T

Abstract Purpose The purpose of this study is to investigate the performance of stretched-type adiabatic spin lock pulses for homogeneous spin locking with a flexible spin lock time (TSL) setting. Methods T 1ρ values were obtained from 61 patients and five normal volunteers who were categorized using the Child–Pugh classification and scanned using each spin lock pulse type. The pulses used were the block and two kinds of hyperbolic secant (HS); HS8_10, and HS8_5. Visual scoring was categorized using a four point scale (1:Severe, 2:Moderate, 3:Mild and 4:None) to evaluate the homogeneity of the T 1ρ map and the source images obtained by each spin lock pulse. Mean T 1ρ values among the patient groups with different Child–Pugh classification were compared. Results The visual assessment scores were 1.98 ± 1.05 for block pulse locking, 3.87 ± 0.39 for HS8_10 pulse locking, and 3.83 ± 0.45 for HS8_5 pulse locking, respectively. The scores between block pulse and HS8_10 were significantly different (p The median T 1ρ values of normal liver function, Child–Pugh A, and Child–Pugh B or C were 37.00 ms, 40.77 ms, and 42.20 ms for block pulse, 46.75 ms, 50.78 ms, and 55.60 ms for HS8_10, and 48.80 ms, 55.42 ms, and 57.80 ms for HS8_5, respectively. Conclusion The spin locking sequence using stretched-type adiabatic pulses provides homogeneous liver T 1ρ maps with reduced artifact and is necessary for a robust evaluation of liver function using T 1ρ .