Single-event transgene-product levels predict levels in genetically modified breeding stacks
2017
The concentration of transgene products (proteins and double-stranded RNA) in genetically modified (GM) crop tissues is measured to support food, feed, and environmental risk assessments. Measurement of transgene-product concentrations in breeding stacks of previously assessed and approved GM events is required by many regulatory authorities to evaluate unexpected transgene interactions that might affect expression. Research was conducted to determine how well concentrations of transgene products in single GM events predict levels in breeding stacks composed of these events. The concentrations of transgene products were compared between GM maize, soybean, and cotton breeding stacks (MON-87427 × MON-89034 × DAS-O15O7-1 × MON-87411 × DAS-59122-7 × DAS-40278-9 corn; DAS-81419-2 × DAS-44406-6 soybean; DAS-21023-5 x DAS-24236-5 x SYN-IR102-7 × MON-88913-8 × DAS-81910-7) and their component single events (MON-87427, MON-89034, DAS-O15O7-1, MON-87411, DAS-59122-7, DAS-40278-9 corn; DAS-81419-2, DAS-44406-6 soybe...
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