Effect of the growth-promoting alpha-globulin (GPAG) on in vitro incorporation of exogenous DNA into mammalian cells

The uptake of exogenous3H-DNA by mammalian cells is increased in the presence of a specific serum protein complex — growth-promoting alpha-globulin (GPAG).3H-DNA is retained in the cell nucleus in a quantity 3 times higher than for control cultures without GPAG even after 47h of additional cultivation in the medium without3H-DNA.