Genetic Polymorphisms of Delta-Like 1 Homolog (DLK1) Influence the Susceptibility to Antituberculosis Drug-Induced Hepatotoxicity.

This study was designed to investigate the relationship between Delta-like 1 homolog (DLK1) polymorphisms and the occurrence of antituberculosis drug-induced hepatotoxicity (ATDH) in the Western Chinese Han population. A total of 746 tuberculosis patients including 118 ATDH cases and 628 non-ATDH cases were enrolled from West China Hospital of Sichuan University during 2016-2018. Ten single nucleotide polymorphisms (rs11160604, rs7149242, rs7141210, rs7155375, rs876374, rs57098752, rs2400940, rs12431758, rs4900472, and rs6575802) within DLK1 were studied by the improved multiplex ligation detection reaction method genotyping technology assay. It was found that G allele of rs11160604 was associated with an increased risk for ATDH (p = 0.001) and G allele of rs4900472 showed a protective effect for ATDH (p = 0.030). Recessive model and dominant model of rs11160604 were observed as a risk factor for ATDH predisposition, whereas the recessive model of rs4900472 was a protective one. Moreover, the interaction genetic model composed of rs11160604, rs57098752, and rs12431758 showed a combined effect for the occurrence of ATDH. Our finding was a novel one indicating that the G allele of DLK1 rs11160604 might serve as a hazard for the development of ATDH in the Western Chinese Han population.