Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Masahiko Kainuma,Jun-ichi Kasuga,Shinnosuke Hosoda,Ken-ichi Wakabayashi,Aya Tanatani,Kazuo Nagasawa,Hiroyuki Miyachi,Makoto Makishima,Yuichi Hashimoto

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

2006

Masahiko Kainuma
Jun-ichi Kasuga
Shinnosuke Hosoda
Ken-ichi Wakabayashi
Aya Tanatani
Kazuo Nagasawa
Hiroyuki Miyachi
Makoto Makishima
Yuichi Hashimoto

Abstract Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor α (PPARα) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

Keywords:

Agonist
Nuclear receptor
Peroxisome proliferator-activated receptor
Diphenylmethane
Farnesoid X receptor
Chemistry
Ligand
Biochemistry
Receptor
Steroid
Stereochemistry

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