Triphenyltin chloride inhibits superoxide production by human neutrophils stimulated with a surface active agent

Abstract Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O − 2 ) production stimulated with phorbol myristate acetate (PMA). TPTCl was more potent as inhibitor of O − 2 production than other phenyltin compounds. The O − 2 production by the xanthine oxidase—acetaldehyde system was not inhibited by TPTCl. This finding indicates that TPTCl does not itself react with O − 2 . Furthermore, TPTCl did not influence the isolated NADPH oxidase at all, though O − 2 production of neutrophils stimulated with PMA in the presence of TPTCl was inhibited. These results indicate that TPTCl inhibits the activation process of the O − 2 generating system.