Reply to comments on: Obesity associated with a novel mitochondrial tRNACys 5802A>G mutation in a Chinese family

: We thank Dr. Finsterer for the inquiry regarding the report about "Responsibility of the variant m.5802A>G in tRNA(Cys) for mitochondrial obesity remains unproven"[1]. Through mitochondrial gene sequencing, bioinformatics analysis and phylogenetic analysis, we believe that this mitochondrial tRNA mutation site may be a risk factor related to obesity. In response to his questions, we make the following explanation.