Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells
2011
Kelly et al. describe antibodies for purifying two progenitor populations that arise during the differentiation of human embryonic stem cells to pancreatic beta cells: pancreatic endoderm and polyhormonal endocrine cells. After transplantation into mice, only pancreatic endoderm cells differentiate into glucose-responsive insulin-producing cells.
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