Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Heng Xu,Giles W. Robinson,Jie Huang,Joshua Yew Suang Lim,Hui Zhang,Johnnie K. Bass,Alberto Broniscer,Murali Chintagumpala,Ute Bartels,Sri Gururangan,Tim Hassall,Michael Fisher,Richard J. Cohn,Tetsuji Yamashita,Tal Teitz,Jian Zuo,Arzu Onar-Thomas,Amar Gajjar,Clinton F. Stewart,Jun J. Yang

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

2015

Jun Yang, Clinton Stewart and colleagues report the results of a genome-wide association study of cisplatin-induced ototoxicity among children undergoing treatment for brain tumors. They identify common variants in ACYP2 strongly associated with cisplatin-induced hearing loss and ototoxicity severity.

Keywords:

ACYP2
Ototoxicity
Hearing loss
Genetics
Cisplatin
Immunology
Genome-wide association study
Chemotherapy
Biology
Acid anhydride hydrolases

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