The last gene involved in the MEP pathway of Artemisia annua: Cloning and characterization and functional identification

Hydroxymethylbutenyl 4-diphosphate reductase (HDR) catalyzes the last reaction of the methylerythritol phosphate (MEP) pathway for the biosynthesis of artemisinin precursors, a branching step that separately produces isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in a ratio of 5:1 to 6:1. The full-length cDNA sequence of HDR was cloned and characterized from